There are several factors in a partial list which enhance the MMP-9 dysfunctional state .
1. Mitogens may stimulate at genomic level
2. Oncogens such as Ras
3. MMP-9 growth factors
4. Inflammatory cytokines (IL-1 beta, TNF-alpha, IL-6?)
5. Nf-kappa gene
6. Processing of inactive proenzyme
7. TGF-beta
8. ELAV proteins such as HuR which stabilizes the mRNA of MMP-9
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