Ex-officio announcemnet: No need for death from cancer

This will be an unofficial announcement pertaining to anyone who personally or who has a relative who is dying from cancer. There is just one culprit involved……Tumor Necrosis Factor-Alpha.

As in the case of the death in toxic shock syndrome the end is shock or cardiovascular collapse. This occurs as a consequence of diminished volume, oncotic pressure (albumin) or pump failure. The greater the chronicity, the greater the loss of albumin, and cardiovascular integrity due to diminished mitochondrial to intercellular functioning.

The body in its preferential assimilation of essential amino acids to synthesize TNF literally digests other non-tumor protein sources within the body. The tumor literally digests other parts of the body in an “intelligent” survival of the fittest as it almost instinctively turns off the feedback inhibition of the production of TNF.

How does it do this? From studies on the over production of mesangium within the kidney we have learned that HuR blocks the normal deterioration of the mMRNA responsible for making various proteins. ( Ethanol promotes HuR attachment to the mRNA of TNF . Yet NO diminishes the mRNA.)

The normal diminution of TNF by IL6 for example, is prevented by increasing its production at the posttranscriptional level.

Nevertheless there is an obligatory receptor necessary for TNF’s action. Without it there
is no TNF action at the genome level. Blocking the receptor allows for blockage of action. The monoclonal antibody to TNF receptor is available now. Its side effects include:

Let us look at other ironies . PLEASE NOTE ORDER TOP TO BOTTOM


Initiator

Prod / Activ
INCREASED

Prod / Activ
decreased

Jnl / Vol / Pg

Author / Yr
Misc / Vol / Ed

TNF

NO2/NO3 (from L-Arginine)/ornithine*
Arginine/putrescine /CTL /inhibition

J parent Nutrition/10/227

Higuchi/90

* Tabor/64/ J biol chem/239/ 2194 / generation of CTL involved /proportionally to /arginine/ornith

Now, the same amino acid of HuR (ELAV) namely arginine if methylated allows for a stabilization of the HuR which diminishes the deterioration of the mRNA of TNF.THE CURE OF THE LETHALITY IN CANCER MAY ALSO REVOLVE AROUND
ORNITHINE/ARGININE PHYSIOLOGY/BIOCHEMISTRY L-arginine is found in high content in protein rich foods such as peanuts, walnuts, Brazil Nuts, coconut, animal products (milk and milk products, pork, beef, chicken, turkey), Sea Foods, cereals (oats and wheat), and chocolate. Legumes such as soybean and chickpea are also rich natural sources of L-arginine.